NSU Research Contributions
Title : V1A VASOPRESSIN RECEPTOR GENE SINGLE NUCLEOTIDE POLYMORPHISM AND ESSENTIAL HYPERTENSION, TYPE 2 DIABETES MELLITUS AND PLATELET AGGREGATION
Authors : Kazi Nadim Hasan, Masaru Shoji, Kazuhiro Sugimoto, Shoji Tsutaya, Eriko Matsuda, Ryoko Kudo, Junko, Saito, Shigeyuki Nakaji, Toshihiro Suda and Minoru Yasujima
Abstract : Candidate gene SNP study is a promising genetic approach to common complex disorders. Arginine vasopressin (AVP), a peptide hormone released from the posterior pituitary, has been suggested to play important roles in the regulation of blood pressure, glycogenolysis, and platelet aggregation through G protein-coupled V1a receptor (V1a). Thus, polymorphisms in the V1a R gene have been prospective as possible genetic markers for essential hypertension, type 2 diabetes mellitus and divergent platelet aggregation response to AVP. We identified four novel single nucleotide polymorphisms (SNPs) in the promoter region of the V1aR gene and named according to the upstream locations such as, -6951G/A, -4112A/T, -3860T/C, and -242C/T. We investigated the association of 4 SNPs of the V1a gene in 365 hypertensive and 255 healthy subjects, 186 T2DM patients and 188 non-diabetic control subjects (CS), and 33 young healthy volunteers living in the Aomori prefecture. A significant association was identified between SNP at -6951 and hypertension in nonobese individuals, and at -6951 and type 2 diabetes mellitus. A positive association was also identified between nonobese hypertension and haplotype H3. A significant association was demonstrated between SNP at -6951 and glycemic status in young healthy subjects. However, there was no significant association in the AVP-induced platelet aggregation with V1aR gene variants. The study suggests V1aR gene variants as an increased risk for hypertension in nonobese and type 2 diabetes mellitus in the Aomori population; however, it might not be useful as genetic markers for platelet aggregation heterogeneity.
| Journal : Hirosaki Medical Journal | Volume : 59 | Year : 2007 | Issue : supplement |
| Pages : S119 - S127 | City : | Edition : | Editors : |
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