NSU Research Contributions

Title : Evaluation of Salvia officinalis on Hippocampal-Dependent Memory Improvement in Obesity Induced Mice Model

Authors : Rezaul Karim Rakib1, Md. Arif Hossain Ayon1 , Md. Al-Wakil Mazumder1, Md. Sabbir Ahamed, Md. Ashrafur Rahman*

Abstract : Objective: The aim of this study was to investigate the effect of Salvia officinalis (Sage) on cholinergic- dependent memory improvement and oxidative stress by using high fat diet-induced obesity (HFDIO) mice model. Background: Obesity, a medical condition is a prominent risk factor for the impairment of memory. HFDIO causes severe impairments in cholinergic-dependent memory through increasing the oxidative burden and reducing synaptic plasticity, and dentate gyrus neurogenesis in rodents brain. Oxidative stress is involved in increasing the acetylcholine esterase (AChE), an enzyme responsible for breakdown of ACh in synapse. Sage inhibits the AChE enzyme and reduce the oxidative level in brain. Method: 20 swiss albino mice (8-10 weeks: 25-35 grams) were divided into 2 groups: Group 1; control (n =10) and Group 2; HFDIO (n =10). HFD was provided for 8 weeks to the group 2. After recording the memory, ethanolic extract of Sage was given orally for 1 month to the group 2. Memory improvement were assessed by using cholinergic-dependent behavioral batteries including novel object recognition (NOR) and contextual fear conditioning (CFC). Paired t-test and ANOVA were used for statistical analyses. SOD, APOP, GSH, NO and MDA level from hippocampus and cortex were analyzed by using bioassay. Results: The HFDIO mice showed remarkable level of body weight (average: 58 grams, P

Journal :	Volume :	Year : 2018	Issue :
Pages : P087	City : Jessore	Edition :	Editors :
Publisher : ICBER 2018	ISBN :	Book :	Chapter :
Proceeding Title : Evaluation of Salvia officinalis on Hippocampal-Dependent Memory Improvement in Obesity Induced Mice Model	Institution :	Issuer :	Number :