Title : Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms

Authors : Luiz Gomes A Júnior, Dimitrova Tchekalarova J, Atanasova M, da Conceição Machado K, de Sousa Rios MA, Paz MFCJ, G?man MA, G?man AM, Yele S, Shill MC, Khan IN, Islam MA, Ali ES, Mishra SK, Islam MT, Mubarak MS, da Silva Lopes L, de Carvalho Melo-Cavalcante AA.

Abstract : Epilepsy is a neurological disease affecting people of all ages worldwide. Side effects of antiepileptic drugs and their association with oxidative stress stimulate the search for new drugs, which would be more affordable with fewer adverse effects. Accordingly, the aim of the present work is to evaluate the anticonvulsant effect of anacardic acid (AA), a natural compound extracted from cashew liquid (Anacardium occidentalis), in murine models, as well as its antioxidant actions in Saccharomyces cerevisiae. AA (> 90% purity) was tested, in vivo, in male Swiss mice (25–30 g) with four convulsive models, (1) pentylenetetrazole, (2) pilocarpine, (3) electroshock, and (4) kainic acid, at doses of 25, 50, and 100 mg/kg, body weight (B.W.) Additionally, the effective dose, toxic dose, and protective index studies were also performed. Results revealed that AA exhibits anticonvulsive effects in models 1, 3, and 4, with a mean effective dose (ED50) of 39.64 (model 1)>100 mg/kg, B.W. (model 2), and 38.36 (model 3); furthermore, AA displays a protection index of 1.49 (model 1),

Journal : Biomedicine & Pharmacotherapy Volume : 106 Year : 2018 Issue :
Pages : 1686 – 1695 City : Edition : Editors :
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