NSU Research Contributions

Title : YABA (METHAMPHETAMINE TABLET) ADMINISTRATION ALTERED CELLULAR ANTIOXIDANT STATUS AND DEVELOPED FIBROSIS IN LIVER OF RAT

Authors : Nasrin Akhter, Md. Ashraful Alam, Md. Anower Hussain Mian, Hasan Mahmud Reza, Md. Saiful Islam

Abstract : The aim of our study was to evaluate the effect of methamphetamine contained Yaba tablet on rat liver, available in Bangladeshi underground market. Yaba tablet equivalent to 5 mg or 10 mg of methamphetamine /kg body weight was administered orally once daily in rat for 56 days. At the end of experiment, all rats were sacrificed; blood and tissue samples were analyzed for alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), advanced oxidation protein product (AOPP), malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH), catalase (CAT) and superoxide dismutase (SOD). Histopathological study of rat liver was done with Hematoxylin and Eosin, Picrosirius Red and Prussian Blue staining from all groups. Yaba powder administration significantly elevated the ALT, AST and ALP activities in plasma of rat. MDA and NO levels were elevated in plasma and tissues. However, AOPP and GSH level in plasma and liver tissue remain unchanged as compared to control rat. CAT and SOD enzyme activities were unaffected. Histological staining revealed that inflammatory cells were deposited alongside the veins in liver followed by collagen deposition after Yaba administration in rat as compared to control rat. The high dose of Yaba produced more significant changes in rat liver. The overall results suggested that longterm administration of Yaba tablet might develop oxidative stress and induce cellular inflammation and fibrosis in rat liver. Thus, hepatic dysfunction by Yaba tablet might manifest in human liver as well.

Journal : PharmacologyOnLine	Volume : 2	Year : 2019	Issue :
Pages : 269-281	City :	Edition :	Editors :
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