NSU Research Contributions
Title : TCF7L2 gene rs7903146 polymorphism is observed in gestational diabetes mellitus in Bangladesh.
Authors : Mashfiqul-Hasan, Hasanat MA , Nadim-Hasan K , Sandesh-Panthi , Yasmin-Aktar , Nusrat-Sultana , Sharmin-Jahan , Atiqur-Rahman M , Mazumder AK , Khaleque M A , Fariduddin M and Sharif-Akhteruzzaman.
Abstract : In the context of an alarming frequency of gestational diabetes mellitus (GDM) observed recently in Bangladesh and a reported stronger association of genetic variants of Transcription factor 7-like 2 (TCF7L2) rs7903146 with risk of GDM, the frequency of this single nucleotide polymorphism (SNP) was studied in Bangladeshi woman. Pregnant women with no past history of glucose intolerance (N=100; age 26.22 ± 4.56 years; body mass index (BMI) 26.39 ± 3.85; mean ± SD; GDM=50, normal glucose tolerance (NGT)=50 according to WHO 2013 criteria) were recruited for the study. TCF7L2 rs7903146 polymorphism was genotyped using Sanger sequencing technique. Mothers with GDM had significantly higher age (27.54 ± 4.45 vs. 24.90 ± 4.33 years, p=0.003; mean ± SD) and BMI (27.15 ± 3.81 vs. 25.62 ± 3.77 kg/m2, p=0.047; mean ± SD) than those of mothers with NGT. Frequency of family history of DM in 1st degree relatives was also significantly higher in women with GDM (50% vs. 22%, p=0.006). CC, CT and TT genotype frequencies of the TCF7L2 rs7903146 varied between women with GDM and NGT (GDM vs. NGT, CC-CT-TT: 56, 40 and 4% vs. 70, 26 and 4% respectively; p=0.323). The T-allele frequency was higher in GDM whereas C-allele frequency in NGT (GDM vs. NGT, T-allele: 24% vs. 17%; C-allele 76% vs. 83%; p=0.220). Women with CT-genotype had a 1.9-fold (95% CI 0.82-4.53, p=0.133) and TT genotype had a 1.2-fold (95% CI 0.17-9.44, p=0.828) increased risk for GDM. It is concluded that the TCF7L2 rs7903146 variant might confer an increased risk of GDM in Bangladeshi women.
| Journal : Integrative Obesity and Diabetes | Volume : 2 | Year : 2016 | Issue : 4 |
| Pages : 250-254 | City : | Edition : | Editors : |
| Publisher : | ISBN : | Book : | Chapter : |
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