NSU Research Contributions
Title : Milling to achieve the appropriate particle properties for inhalation, how can we rank or predict?
Authors : Mohammad Hossain Shariare & Frank J. J. Leusen & Marcel de Matas & Peter York & Jamshed Anwar
Abstract : Purpose To explore the use of crystal inter-planar d-spacings and slip-plane interaction energies for predicting and characterising mechanical properties of crystalline solids. Methods Potential relationships were evaluated between mechanical properties and inter-planar d-spacing, interplanar interaction energy, and dispersive surface energy as determined using inverse gas chromatography (IGC) for a set of pharmaceutical materials. Inter-planar interaction energies were determined by molecular modelling. Results General trends were observed between mechanical properties and the largest inter-planar d-spacing, interplanar interaction energies, and IGC dispersive surface energy. A number of materials showed significant deviations from general trends. Weak correlations and outliers were rationalised. Conclusions Results suggest that the highest d-spacing of a material could serve as a first-order indicator for ranking mechanical behaviour of pharmaceutical powders, but with some reservation. Inter-planar interaction energy normalised for surface area shows only a weak link with mechanical properties and does not appear to capture essential physics of deformation. A novel framework linking mechanical properties of crystals to the distinct quantities, slip-plane energy barrier and inter-planar interaction (detachment) energy is proposed.
| Journal : | Volume : | Year : 2011 | Issue : |
| Pages : | City : Bath, UK | Edition : | Editors : |
| Publisher : Academy of Pharmaceutical Sciences, UK | ISBN : | Book : | Chapter : |
| Proceeding Title : APS Inhalation’ University of Bath, UK | Institution : | Issuer : | Number : |