NSU Research Contributions
Title : RoleofMuscarinicAcetylcholineReceptorsin SerialFeature-Positive DiscriminationTask duringEyeblinkConditioninginMice
Authors : Md. Ashrafur Rahman, Norifumi Tanaka, Koji Usui, Shigenori Kawahara
Abstract : Weinvestigated theroleofmuscarinicacetylcholinereceptors(mAChRs)ineyeblinkserial feature-positivediscrimination learning inmiceusingthemAChR antagonist.A2-slightcue wasdelivered 5or6sbeforethepresentationofa350-mstonepairedwitha100-msperiorbitalelectricalshock(cuedtrial)butnotbeforethetone-alonepresentation(non-cuedtrial). Micereceived30cuedand30non-cuedtrials eachdayinarandomorder.Wefoundthat saline-injectedcontrolmiceweresuccessfullydiscriminatingbetweencuedandnon-cued trialswithinafewdaysofconditioning.Themicerespondedmorefrequentlytothetone incuedtrialsthaninnon-cuedtrials.Analysisofconditionedresponse(CR)dynamics revealedthattheCRonsetlatencywasshorterincuedtrials thaninnon-cuedtrials,despite theCRpeakamplitudenotdifferingsignificantlybetweenthetwoconditions.Incontrast, scopolamine-injected micedevelopedanequalnumberofCRswithsimilartemporalpatternsirrespectiveofthepresenceofthecueduringthe7daysofconditioning,indicatingin afailuretoacquireconditionaldiscrimination.Inaddition,thescopolamineadministration tothecontrolmiceaftertheyhadsuccessfullyacquireddiscriminationdidnotimpairthe conditionaldiscriminationandexpressionofpre-acquiredCR.Theseresultssuggestthat mAChRsmayplayapivotalroleinmemoryformationintheconditionalbrainstateassociatedwiththefeature cue;howevertheyareunlikelytobeinvolvedinthedevelopmentof discriminationafterconditionalmemoryhadformedintheserialfeature-positivediscriminationtaskduringeyeblinkconditioning.
Journal : PLOs ONE | Volume : PLoSONE11(1): e0147572. | Year : 2016 | Issue : PLoS ONE 11(1) |
Pages : | City : | Edition : | Editors : |
Publisher : | ISBN : | Book : | Chapter : |
Proceeding Title : | Institution : | Issuer : | Number : |