NSU Research Contributions
Title : COVID-19 hospitalization with later long COVID in a person with Down syndrome
Authors : Mohammad Ashraful Amin, Ishtiakul Islam Khan, Sabrina Nahin, Atia Sharmin Bonna, Sadia Afrin, and Mohammad Delwer Hossain Hawlader
| Journal Article Title: Clinical Case Reports | Volume Number: 10 | Publication Year : 2022 | Issue Number: 10 |
| Index: scopus | Ranking: Q3 | ISSN (Print): 2050-0904 | Publisher Name: John Wiley & Sons, Inc. |
| Pages : 9 | |||
| ISSN (Online): 2050-0904 | |||
| Funding Source : None |
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Direct Sustainable Development Goals : SDG3 Good Health & Well-being |
Indirect Sustainable Development Goals : SDG10 Reduced Inequality |
Sustainable Development Sub Goals : End the epidemics of AIDS, tuberculosis, malaria and neglected tropical diseases Achieve universal health coverage |
| Impact statement: This case report documents the first recorded instance in Bangladesh of an adult with Down syndrome experiencing "long COVID"—specifically, persistent muscle and joint pain lasting more than 12 weeks after initial infection. The study explains that individuals with trisomy 21 are biologically predisposed to severe COVID-19 outcomes due to immune dysregulation and interferon hyperactivity, which can trigger a massive cytokine storm. By establishing that mortality risks for this population begin to rise significantly at age 40, much younger than the general public, the research provides a vital evidence-based mandate for health authorities to prioritise people with Down syndrome for early vaccination and to update monitoring standards to include annual musculoskeletal examinations. | Collaboration: None | Keywords: Down syndrome, COVID-19, Long COVID, Trisomy 21, Bangladesh, Case report |
