NSU Research Contributions

Title : Nrf2-Mediated Supersulfide Bridging for Mitochondrial Function.

Authors : Md. Morshedul Alam

Abstract : In eukaryotic cells, mitochondria serve as the energy power-house. Through proper electron transport chain to get ATP, and mitochondrial membrane potential (MMP) are the common manifestation of mitochodrial functions. Mitochondria are also regarded as the redox reaction cellular organelle. NRF2-KEAP1 system acts as the major redox homeostatic system in the biological environment. In some studies, it was observed that impaired NRF2-KEAP1 system reduces mitochondrial function but the underlying mechanism was not well studied. Alam et al (2023), in their recent study proved that NRF2 regulates the supersulfide species generation by increasing the availability and its further metabolism directly modulates the mitochondrial function, which has been focused here.

Journal : EC Pharmacology and Toxicology	Volume : 13	Year : 2025	Issue : 7
Pages :	City :	Edition :	Editors :
Publisher :	ISBN :	Book :	Chapter :
Proceeding Title :	Institution :	Issuer :	Number :