NSU Research Contributions
Title : Prevalence of Gilbert Syndrome in Bangladesh
Authors : Sanjana Zaman, Hiroko Fukushima, Ryoko Suzuki, Mohammad Delwer Hossain Hawlader, Shoji Yoshimatsu, Yu Kanai, Gias U. Ahsan, and Takashi Fukushima
| Journal Article Title: Open Journal of Blood Diseases (OJBD) | Volume Number: 8 | Publication Year : 2018 | Issue Number: 1 |
| Index: indexed | Ranking: No Ranking | ISSN (Print): 2164-3180 | Publisher Name: Scientific Research Publishing Inc. (SCIRP) |
| Pages : 9 | |||
| ISSN (Online): 2164-3199 | |||
| Funding Source : None |
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Direct Sustainable Development Goals : SDG3 Good Health & Well-being |
Indirect Sustainable Development Goals : SDG4 Quality Education SDG10 Reduced Inequality |
Sustainable Development Sub Goals : Reduce premature mortality from non-communicable diseases and promote mental health and well-being Achieve universal health coverage Ensure enhanced representation and voice for developing countries in global decision-making |
| Impact statement: This study is the first to identify the prevalence of Gilbert Syndrome (GS) in Bangladesh, revealing a significantly high frequency of the UGT1A1 28 polymorphism (44.2%). The research highlights critical clinical implications: infants with this genetic variation are at a higher risk of developing neonatal jaundice and severe complications like Kernicterus, while adult patients may experience life-threatening toxicities when treated with certain chemotherapy drugs like irinotecan. By establishing that GS is a common condition in the region, the authors provide a vital alert for clinicians to implement routine genotyping before treatment, ensuring safer pharmacological interventions and better neurodevelopmental outcomes for newborns. | Collaboration: Partner University | Keywords: Gilbert Syndrome, Uridine Diphosphate Glucuronosyl Transferase |
