NSU Research Contributions
Title : TPMT and ITPA Gene Polymorphism and Their Adverse Events during Chemotherapy of Acute Lymphoblastic Leukemia among Bangladeshi Children
Authors : Sanjana Zaman, Hiroko Fukushima, Ryoko Suzuki, Shoji Yoshimatsu, Mohammad Delwer Hossain Hawlader, and Takashi Fukushima
| Journal Article Title: Iranian Journal of Blood & Cancer (IJBC) | Volume Number: 11 | Publication Year : 2019 | Issue Number: 3 |
| Index: scopus | Ranking: Q2 | Publisher Name: Iranian Pediatric Hematology & Oncology Society | |
| Pages : 5 | |||
| Funding Source : None |
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Direct Sustainable Development Goals : SDG3 Good Health & Well-being |
Indirect Sustainable Development Goals : SDG10 Reduced Inequality |
Sustainable Development Sub Goals : Reduce premature mortality from non-communicable diseases and promote mental health and well-being Achieve universal health coverage |
| Impact statement: This landmark study is the first molecular analysis from Bangladesh to identify the genetic determinants of chemotherapy-induced toxicity in children with Acute Lymphoblastic Leukemia (ALL). The research highlights a high prevalence of the ITPA variant (0.153), revealing that patients with this polymorphism are 7.68 times more likely to suffer from absolute neutropenia and significantly more prone to liver toxicity and fever during treatment with 6-mercaptopurine. By establishing these links, the authors provide a vital roadmap for individualized medicine, arguing that routine genetic screening before starting chemotherapy can help clinicians design safer, more rational treatment strategies to protect the most vulnerable pediatric patients. | Collaboration: Other | Keywords: TPMT gene polymorphisms, ITPA enzyme Polymorphism, Acute lymphoblastic leukemia, Children, 6-mercaptopurine toxicity |
