NSU Research Contributions
Title : Anti-Ascaris immunoglobulin E associated with bronchial hyper-reactivity in 9-year-old rural Bangladeshi children
Authors : Haruko Takeuchi, Al Fazal Khan, Mohammad Yunus, Mohammad Imrul Hasan, Mohammad Delwer Hossain Hawlader, Sayaka Takanashi, Hirotsugu Kano, Khalequz Zaman, Hafizur R. Chowdhury, Yukiko Wagatsuma, Shinji Nakahara, and Tsutomu Iwata
| Journal Article Title: Allergology International | Volume Number: 65 | Publication Year : 2016 | Issue Number: 2 |
| Index: scopus | Ranking: Q1 | Publisher Name: Elsevier B.V. | |
| Pages : 6 | |||
| ISSN (Online): 1323-8930 | |||
| Funding Source : None |
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Direct Sustainable Development Goals : SDG3 Good Health & Well-being |
Indirect Sustainable Development Goals : SDG10 Reduced Inequality |
Sustainable Development Sub Goals : Reduce premature mortality from non-communicable diseases and promote mental health and well-being Achieve universal health coverage |
| Impact statement: This randomized study of 9-year-old children in rural Bangladesh confirms that anti-Ascaris IgE levels are significantly associated with an increased risk of bronchial hyper-responsiveness (BHR), even in areas where the infection is highly endemic. The research demonstrates that BHR is 7.30 times more likely in children with high anti-Ascaris IgE levels, and this association remains significant even after adjusting for factors like pneumonia history, total IgE, and parental asthma. Crucially, the study suggests that the immune reactivity to the parasite (IgE), rather than the current infection itself, is the primary driver of asthma-like symptoms. These findings serve as a vital call for clinicians to recognize Ascaris-specific IgE as a major independent risk factor for childhood asthma in tropical and developing regions. | Collaboration: Other | Keywords: Antigen specific IgE, Bronchial hyper-responsiveness, Childhood asthma, Lung function tests, Nematode infections |
