Title : A case of acute encephalopathy and non-ST segment elevation myocardial infarction following mRNA-1273 vaccination: possible adverse effect?


Authors : Sabrina Yesmin Barsha, Miah Md. Akiful Haque, Md Utba Rashid, Mohammad Lutfor Rahman, Mohammad Ali Hossain, Sanjana Zaman, Elias Bhuiyan, Rahima Sultana, Mosharop Hossian, Mohammad Hayatun Nabi, Mohammad Delwer Hossain Hawlader


Journal Article Title: Clinical and Experimental Vaccine Research (Clin Exp Vaccine Res) Volume Number: 10 Publication Year : 2021 Issue Number: 3
Index: scopus Ranking: Q2 ISSN (Print): 2287-3651 Publisher Name: Korean Vaccine Society
Pages : 5
ISSN (Online): 2287-366X
Funding Information:
Funding Source : None
Other Information:
Direct Sustainable Development Goals :
SDG3 Good Health & Well-being
Indirect Sustainable Development Goals :
SDG10 Reduced Inequality
Sustainable Development Sub Goals :
Reduce premature mortality from non-communicable diseases and promote mental health and well-being
Achieve universal health coverage
Ensure enhanced representation and voice for developing countries in global decision-making
Impact statement: This case report documents a 77-year-old male in Bangladesh who developed acute encephalopathy and non-ST-segment elevation myocardial infarction (NSTEMI) within 48 hours of receiving the Moderna (mRNA-1273) COVID-19 vaccine. The patient, who had existing comorbidities, exhibited significantly high inflammatory markers (CRP, ESR, D-dimer) shortly after vaccination. While the authors emphasize that a direct causal link cannot be established without larger epidemiological studies, the report serves as an essential clinical alert to help healthcare providers identify and manage rare neurological and cardiac complications, thereby supporting the safe implementation of mass immunization programs. Collaboration: Other Keywords: Non-ST elevated myocardial infarction; Encephalopathy; COVID-19; Bangladesh; Moderna vaccine; Case report